CD137 siRNA (h), shRNA and Lentiviral Particle Gene Silencers are designed to knockdown gene expression of human CD137.
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
BTLA. VISTA. LAG-3. HVEM. CD27. CD137.
4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. EphA2/CD137 TICAs which engage EphA2 and CD137 simultaneously with high affinity resulting in picomolar potency. EphA2/CD137 TICAs potentiate tumor target dependent cytokine secretion in immune co-culture experiments and promote caspase activity in T cell mediated cell killing assays. investigated the effects of CD137 signalling, demonstrating that binding of the CD137 ligand to its receptor increases proliferation and migration of smooth muscle cells. In summary, this thesis has focused on the expression, regulation and role of CXCL16 and CD137, two genes that have not been described earlier in the concept of atherosclerosis. CD137-transfected L-428 cells (L-428-CD137) were treated with 10 μg/ml of Fabs, followed by anti-Fab-AF647. All Fabs bound efficiently to CD137 + cells ( Supplementary Figure 3 ).
Anti-CD137 mAb is currently undergoing phase I and II clinical trials for cancer [28]. In preclinical models, immunotherapeutic doses of CD137-speciWc mAb have not shown serious deleterious eVects. Described toxic eVects include myelosuppression [33] mediated by cytokines released in the bone marrow microenvironment.
Recombinant Human CD137 Protein (Met1-Gln186) ECD 10041-H08H with a fusion His Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human CD137 protein for relevant bioassay and related research. CD137 is expressed on activated T cells, B cells, monocytes, and follicular dendritic cells. CD137 plays roles in the costimulation, differentiation and survival of T cells and B cells.
CD137 has also been evaluated as a target molecule to selectively deplete alloreactive T cells in vitro [147]. Compared with other activation-induced antigens, CD137 showed a superior performance based on a consistently low baseline expression and a rapid upregulation following alloantigen stimulation.
CD137 is a kind of surface glycoprotein, which was originally discovered in the late 1980s. 6 It has been found that CD137 is expressed in a vari- ety of cells, for example, T cells, B cells, natural killer (NK) cells, dendritic CD137 (TNFSFR9) was originally identified as a molecule induced on the surface of activated mouse and human CD4+ and CD8+ T cells, with its expression undetectable on non-activated T cells. It is also found on both NK and dendritic cells. CD137. CD137 expressed on blood vessels in inflamed tissue correlates with markers of vascular inflammation, and the use of an anti-CD137 antibody promotes the accumulation of T cells in atherosclerotic lesions in a murine model [63]. From: Journal of Autoimmunity, 2020.
BTLA. VISTA. LAG-3.
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It is a member of the TNFR family and CD137 Antibody (BBK-2) is a monoclonal anti-CD137 antibody that detects human CD137 by WB, IP, IF and FCM. The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein 1 Jan 2021 Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune CD137, или TNFRSF9 — мембранный белок, рецептор из надсемейства рецепторов фактора некроза опухоли. У человека кодируется геном TNFRSF9. CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family. CD137 is 4-1BB, also known as CD137, is a type I transmembrane glycoprotein and member of the TNF receptor superfamily with roles in T cell-mediated immunity.
CD137 engagement reduces follicular dendritic cell networks in a T cell-dependent manner.
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tidigare hade fått behandling med docetaxel, CD137-agonister, anti-CTLA4 eller terapier riktade mot PD-L1 och PD-1. Patienter stratifierades
CD137 has also been evaluated as a target molecule to selectively deplete alloreactive T cells in vitro [147]. Compared with other activation-induced antigens, CD137 showed a superior performance based on a consistently low baseline expression and a rapid upregulation following alloantigen stimulation. CD137 is a kind of costimulatory molecule that mediates T cell activation, which regulates the activity of immune cells in a variety of physiological and pathological processes.
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Anti-CD137 mAb is currently undergoing phase I and II clinical trials for cancer [28]. In preclinical models, immunotherapeutic doses of CD137-speciWc mAb have not shown serious deleterious eVects. Described toxic eVects include myelosuppression [33] mediated by cytokines released in the bone marrow microenvironment.
CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses (1). The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis (2).